In [7] and [8], Iemhoff introduced a connection between the existence of a terminating sequent calculus of a certain kind and the uniform interpolation property of the super-intuitionistic logic that the calculus captures. In this paper, we will generalize this relationship to also cover the substructural setting on the one hand and a more powerful type of systems called semi-analytic calculi, on the other. To be more precise, we will show that any suciently strong substructural logic with a semi-analytic calculus has Craig interpolation property and in case that the calculus is also terminating, it has uniform interpolation. This relationship then leads to some concrete applications. On the positive side, it provides a uniform method to prove the uniform interpolation property for the logics FL_e, FL_ew, CFL_e, CFL_ew, IPC, CPC and some of their K and KD-type modal extensions. However, on the negative side the relationship nds its more interesting application to show that many substructural logics including L_n, G_n, BL, R and RM^e, almost all super-intutionistic logics (except at most seven of them) and almost all extensions of S4 (except thirty seven of them) do not have a semi-analytic calculus. It also shows that the logic K4 and almost all extensions of the logic S4 (except six of them) do not have a terminating semi-analytic calculus.